Porcine gelatin sponge12/31/2023 ![]() ![]() Moreover, hemostats left in the injury site and used in directly guiding in situ tissue regeneration are more practical for clinical application 9. Rapid shape recovery timely exerts pressure on the wound, leading to effective hemorrhage control 6, 8. Notably, an interconnected porous structure permits fluid to flow freely in and out of hemostats, which allows hemostats to be fixed by draining off the free water and promotes fast recovery to their initial shapes by absorbing the fluid 6. In general, ideal shape-memory hemostats should possess several properties, including a highly interconnected porous structure, active coagulation, strong anti-infection activity, biocompatibility, biodegradability, ready availability, low weight, and low cost 4, 5, 6, 7. Thus, the development of shape-memory hemostats is urgently needed. The body’s natural coagulation cascade process is activated in response to bleeding, but, incapable of timely stopping severe hemorrhage from a deep and noncompressible perforation wound in the absence of shape-memory hemostats 3, 4. So, rapid and efficient hemorrhage control is of paramount importance in such scenarios. Hypotension and multi-organ failure caused by massive blood loss often results in high mortality in civilian and military populations 1, 2. Overall, the MACS demonstrates promising clinical translational potential in treating lethal noncompressible hemorrhage and facilitating wound healing. ![]() coli and its promotion of liver parenchymal cell infiltration, vascularization, and tissue integration in a rat liver defect model. We demonstrate its anti-infective activity against S. We show that compared to clinically used gauze, gelatin sponge, CELOX™, and CELOX™-gauze, the MACS provides higher pro-coagulant and hemostatic capacities in lethally normal and heparinized rat and pig liver perforation wound models. We demonstrate that the microchannelled alkylated chitosan sponge (MACS) exhibits the capacity for water and blood absorption, as well as rapid shape recovery. Here we engineer hemostatic chitosan sponges with highly interconnective microchannels by combining 3D printed microfiber leaching, freeze-drying, and superficial active modification. Developing an anti-infective shape-memory hemostatic sponge able to guide in situ tissue regeneration for noncompressible hemorrhages in civilian and battlefield settings remains a challenge. ![]()
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